Chemical Structure : STA-013
CAS No.:
STA-013
(STA013)
Catalog No.: PC-25245Not For Human Use, Lab Use Only.
STA-013 is a potent, selective pan-EphB tyrosine kinase inhibitor with IC50 of 0.69, 1.73 and 1.02 uM for EphB1, EphB2 and EphB4 respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
STA-013 is a potent, selective pan-EphB tyrosine kinase inhibitor with IC50 of 0.69, 1.73 and 1.02 uM for EphB1, EphB2 and EphB4 respectively.
STA-013 (0-20 uM) inhibits the lipid accumulation after differentiation to adipocytes in the embryonic mouse 3T3-L1 fibroblast.
STA-013 modulated the mitochondrial respiration and inhibited fatty acid oxidation.
STA-013 promoted whole-body weight loss, restored glucose homeostasis, and mitigated insulin resistance in a high-fat diet (HFD)-induced obesity mouse model.
STA-013 (25 mg/kg, i.p for 6 weeks) improved insulin signaling in isolated brown adipose tissues and livers of HFD-induced obese mice.
Physicochemical Properties
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M.Wt
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411.48
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Formula
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C24H17N3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((1-benzoyl-1H-indol-4-yl)methyl)thieno[2,3-b]pyridine-2-carboxamide
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References
1. Tareq S, et al. Pharmacol Res. 2025 Aug 4:107900.
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