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STA-21

Chemical Structure : STA-21

CAS No.: 28882-53-3

STA-21 (STA21, NSC 628869, Ochromycinone)

Catalog No.: PC-70249Not For Human Use, Lab Use Only.

STA-21 (NSC 628869, Ochromycinone) is a small-molecule inhibitor of STAT3, inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity (20-30 uM).

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Biological Activity

STA-21 (NSC 628869, Ochromycinone) is a small-molecule inhibitor of STAT3, inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity (20-30 uM).
STA-21 reduces the survival of breast carcinoma cells with constitutive Stat3 signaling.
STA-21 inhibits cell viability and growth and induces apoptosis through caspases 3, 8 and 9 pathways in human sarcoma cell lines.

Physicochemical Properties

M.Wt 306.3
Formula C19H14O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3S)-3,4-dihydro-8-hydroxy-3-methyl-benz[a]anthracene-1,7,12(2H)-trione

References

1. Song H, et al. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4700-5.

2. Chen CL, et al. BMC Cancer. 2007 Jun 28;7:111.

3. Fuh B, et al. Br J Cancer. 2009 Jan 13;100(1):106-12.

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