Chemical Structure : STARD7 inhibitor M4
CAS No.:
443110-69-8
STARD7 inhibitor M4
Catalog No.: PC-28118Not For Human Use, Lab Use Only.
STARD7 inhibitor M4 is a small molecule inhibitor of lipid transfer protein STARD7, shows broad-spectrum anti-influenza virus activity with IC50 of <0.6 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
STARD7 inhibitor M4 is a small molecule inhibitor of lipid transfer protein STARD7, shows broad-spectrum anti-influenza virus activity with IC50 of <0.6 uM.
M4 potently inhibits influenza B/Yamagata/16/88 virus with an IC50 of 0.03 μM, and an attenuated highly pathogenic avian influenza H5N1 strain (A/Vietnam/1203/04 HALo), with an IC50 of 0.09 μM.
M4 is also potent against influenza A/Wyoming/03/03 (H3N2) and influenza A/California/04/2009 (H1N1) viruses, yielding IC50s of 0.12 μM and 0.2 μM, respectively.
M4 inhibits nuclear export of the vRNP complex, does not inhibit viral entry.
M4 demonstrates in vivo antiviral activity and enhances the efficacy of baloxavir in a mouse model of influenza A virus infection.
Physicochemical Properties
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M.Wt
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385.31
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Formula
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C18H12FN3O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 2-(2-fluoro-5-nitrobenzamido)-1-oxo-1,2-dihydroisoquinoline-4-carboxylate
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References
1. Sharma S, et al. PLoS Pathog. 2026 Sep 11;22(9):e1013914.
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