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STAT5-IN-1

Chemical Structure : STAT5-IN-1

CAS No.: 285986-31-4

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STAT5-IN-1

Catalog No.: PC-61311Not For Human Use, Lab Use Only.

STAT5-IN-1 is a selective, small molecule inhibitor of the transcription factor STAT5 with IC50 of 47±17 uM in FP assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

STAT5-IN-1 is a selective, small molecule inhibitor of the transcription factor STAT5 with IC50 of 47±17 uM in FP assays.
STAT5-IN-1 shows little to no inhibition for STAT1, STAT3 and Lck (<40% inhibition at 500 uM).
STAT5-IN-1 selectively inhibits the function of the STAT5b domain and STAT5 DNA binding in vitro, and selectively inhibits activation of STAT5 in K562 cells.

Physicochemical Properties

M.Wt 293.28
Formula C16H11N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Pyridinecarboxylic acid, [(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide (9CI)

References

1. Müller J, et al. Chembiochem. 2008 Mar 25; 9(5):723-7.

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