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STD-101-D1

Chemical Structure : STD-101-D1

CAS No.: 2151041-09-5

STD-101-D1

Catalog No.: PC-61776Not For Human Use, Lab Use Only.

STD-101-D1 is a novel brain permeable, G protein-biased beta-1 adrenergic receptor (ADRB1) partial agonist with EC50 of 16.9 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

STD-101-D1 is a novel brain permeable, G protein-biased beta-1 adrenergic receptor (ADRB1) partial agonist with EC50 of 16.9 nM; engages very little beta-arrestin recruitment compared to the unbiased agonist isoproterenol; also inhibits the acute peripheral and CNS TNFα response induced by LPS both in vitro and in vivo.

Physicochemical Properties

M.Wt 333.384
Formula C18H23NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-(2-hydroxy-3-((2-(2-methoxyphenoxy)ethyl)amino)propoxy)phenol

References

1. Yi B, et al. PLoS One. 2017 Jul 26;12(7):e0180319.

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