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STF-1084

Chemical Structure : STF-1084

CAS No.: 2298390-71-1

STF-1084 (STF1084)

Catalog No.: PC-72236Not For Human Use, Lab Use Only.

STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.

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Biological Activity

STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.
STF-1084 has low activity towards the closely related ectonucleotidases alkaline phosphatase (Ki,app>100 μM) and ENPP2 (Ki,app=5.5 μM), as well as against a panel of 468 kinases.
STF-1084 (10 uM) could completely block extracellular cGAMP degradation in ENPP1 overexpressing 293T cGAS cells, without effect on intracellular cGAMP.
STF-1084 rescued extracellular cGAMP levels in the media and induction of IFNB1 expression in CD14+ cells, wothout effect on cytokine production when cGAMP was electroporated into primary human PBMCs.

Physicochemical Properties

M.Wt 381.369
Formula C17H24N3O5P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)ethyl)phosphonic acid

References

1. Jacqueline A Carozza, et al. Nat Cancer. 2020 Feb;1(2):184-196.

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