Catalog No.: PC-72236Not For Human Use, Lab Use Only.
STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.
STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.
STF-1084 has low activity towards the closely related ectonucleotidases alkaline phosphatase (Ki,app>100 μM) and ENPP2 (Ki,app=5.5 μM), as well as against a panel of 468 kinases.
STF-1084 (10 uM) could completely block extracellular cGAMP degradation in ENPP1 overexpressing 293T cGAS cells, without effect on intracellular cGAMP.
STF-1084 rescued extracellular cGAMP levels in the media and induction of IFNB1 expression in CD14+ cells, wothout effect on cytokine production when cGAMP was electroporated into primary human PBMCs.
