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Chemical Structure : STF-118804
CAS No.: 894187-61-2
Catalog No.: PC-43221Not For Human Use, Lab Use Only.
STF-118804 is a potent, highly specific NAMPT inhibitor, reduces the viability of most B-ALL cell lines with high potency in the low nanomolar range (MV411 cell IC50= 6 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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STF-118804 (STF118804) is a potent, highly specific NAMPT inhibitor, reduces the viability of most B-ALL cell lines with high potency in the low nanomolar range (MV411 cell IC50= 6 nM).
STF-118804 induces leukemia cell apoptosis without antecedent cell cycle arrest, shows potency in various cancer cells including high selectivity for colon and prostate cell line in an NCI-60 cell line panel screen.
STF-118804 is highly efficacious in vivo and effectively depletes leukemia stem cells.
| M.Wt | 461.5328 | |
| Formula | C25H23N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-[5-methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)- |
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1. Matheny CJ, et al. Chem Biol. 2013 Nov 21;20(11):1352-63.
2. Espindola-Netto JM, et al. Oncotarget. 2017 Jun 29;8(49):85054-85067.
3. Deng H, et al. Neurochem Res. 2016 Sep;41(9):2367-79.
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