Catalog No.: PC-38280Not For Human Use, Lab Use Only.
STF-1623 (ENPP1 inhibitor 32) is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM, IC50 of 0.6 and 0.4 nM for human and mouse ENPP1 respectively.
STF-1623 (ENPP1 inhibitor 32) is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM, IC50 of 0.6 and 0.4 nM for human and mouse ENPP1 respectively.
ENPP1 inhibitor 32 prevents cGAMP degradation in mouse and human plasma at nanomolar concentrations (IC95=40 nM).
ENPP1 inhibitor 32 exhibits excellent physicochemical and pharmacokinetic properties, and delays tumor growth in a breast cancer mouse model.
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2. Johnson RM, et al. bioRxiv [Preprint]. 2025 May 22:2025.05.18.654655.
