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STING PROTAC SP23

Chemical Structure : STING PROTAC SP23

CAS No.: 2762552-74-7

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STING PROTAC SP23

Catalog No.: PC-38566Not For Human Use, Lab Use Only.

SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.
    SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway.

    Physicochemical Properties

    M.Wt 699.677
    Formula C34H33N7O10
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)-N4-(4-(5-nitrofuran-2-carboxamido)phenyl)fumaramide

    References

    1. Jin Liu, et al. J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.1c01948.

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