STING activator Compound 11

Chemical Structure : STING activator Compound 11

Catalog No.: PC-73369Not For Human Use, Lab Use Only.

STING activator Compound 11 is a potent, small molecule activator/agonist of human STING with EC50 of 66 nM (HEK, R232).

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Biological Activity

STING activator Compound 11 is a potent, small molecule activator/agonist of human STING with EC50 of 66 nM (HEK, R232).
Compound 11 showed significantly enhanced potency compared with G10.

Physicochemical Properties

M.Wt	492.464
Formula	C24H17F5N2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,5-difluorobenzyl)-2-methyl-3-oxo-N-(2,4,6-trifluorobenzyl)-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide

References

1. Monali Banerjee, et al. PLoS One. 2020 Sep 10;15(9):e0237743.

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