STING activator Compound 8

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Chemical Structure : STING activator Compound 8

Catalog No.: PC-73370Not For Human Use, Lab Use Only.

STING activator Compound 8 is a potent, small molecule activator/agonist of human STING with EC50 of 122 nM (HEK, R232), HAQ STING EC50 of 944 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

STING activator Compound 8 is a potent, small molecule activator/agonist of human STING with EC50 of 122 nM (HEK, R232), HAQ STING EC50 of 944 nM.
Compound 8 showed significantly enhanced potency compared with G10.
Compound 8 activated multiple STING variants overexpressed in HEK293T cells measured by luciferase reporter assay or phosphorylation of STING and phosphorylated STING in human PBMCs from multiple donors and human tumor lines.

Physicochemical Properties

M.Wt	508.916
Formula	C24H17ClF4N2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-chloro-6-fluorobenzyl)-2-methyl-3-oxo-N-(2,4,6-trifluorobenzyl)-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide

References

1. Monali Banerjee, et al. PLoS One. 2020 Sep 10;15(9):e0237743.

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