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STING activator Compound 8

Chemical Structure : STING activator Compound 8

CAS No.: 2259341-74-5

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STING activator Compound 8

Catalog No.: PC-73370Not For Human Use, Lab Use Only.

STING activator Compound 8 is a potent, small molecule activator/agonist of human STING with EC50 of 122 nM (HEK, R232), HAQ STING EC50 of 944 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    STING activator Compound 8 is a potent, small molecule activator/agonist of human STING with EC50 of 122 nM (HEK, R232), HAQ STING EC50 of 944 nM.
    Compound 8 showed significantly enhanced potency compared with G10.
    Compound 8 activated multiple STING variants overexpressed in HEK293T cells measured by luciferase reporter assay or phosphorylation of STING and phosphorylated STING in human PBMCs from multiple donors and human tumor lines.

    Physicochemical Properties

    M.Wt 508.916
    Formula C24H17ClF4N2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-chloro-6-fluorobenzyl)-2-methyl-3-oxo-N-(2,4,6-trifluorobenzyl)-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide

    References

    1. Monali Banerjee, et al. PLoS One. 2020 Sep 10;15(9):e0237743.

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