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Chemical Structure : STING activator Compound 8
Catalog No.: PC-73370Not For Human Use, Lab Use Only.
STING activator Compound 8 is a potent, small molecule activator/agonist of human STING with EC50 of 122 nM (HEK, R232), HAQ STING EC50 of 944 nM.
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STING activator Compound 8 is a potent, small molecule activator/agonist of human STING with EC50 of 122 nM (HEK, R232), HAQ STING EC50 of 944 nM.
Compound 8 showed significantly enhanced potency compared with G10.
Compound 8 activated multiple STING variants overexpressed in HEK293T cells measured by luciferase reporter assay or phosphorylation of STING and phosphorylated STING in human PBMCs from multiple donors and human tumor lines.
| M.Wt | 508.916 | |
| Formula | C24H17ClF4N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Monali Banerjee, et al. PLoS One. 2020 Sep 10;15(9):e0237743.
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