Chemical Structure : STING agonist 12b
CAS No.:
2411100-70-2
STING agonist 12b
(Compound 12b)
Catalog No.: PC-24560Not For Human Use, Lab Use Only.
STING agonist 12b is a small molecule STING agonist with EC50 of 7.45 uM and 10.23 uM for human and murine STING respectively and Emax>100% for both, directly binds to carboxy-terminal domain (CTD) (IC50=1.92 uM) and stabilizes the hSTING protein.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
STING agonist 12b is a small molecule STING agonist with EC50 of 7.45 uM and 10.23 uM for human and murine STING respectively and Emax>100% for both, directly binds to carboxy-terminal domain (CTD) (IC50=1.92 uM) and stabilizes the hSTING protein.
STING agonist 12b displays approximately similar activities to 2′3′-cGAMP at activating both human and murine STING.
STING agonist 12b induces diverse cytokines production in a native system.
STING agonist 12b exhibits the tremendous potential to be a better direct-human-STING agonist than 2′3′-cGAMP.
Physicochemical Properties
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M.Wt
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253.30
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Formula
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C16H15NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-methoxy-5,6-dimethylacridin-9(10H)-one
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References
1. Shi Hou, et al. Bioorg Chem. 2020 Jan:95:103556.
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