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Chemical Structure : STING agonist BNBC
Catalog No.: PC-73024Not For Human Use, Lab Use Only.
STING agonist BNBC (BNBC) is a human STING specific agonist that activates cGAS-STING pathway in a functional human STING-dependent manner.
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STING agonist BNBC (BNBC) is a human STING specific agonist that activates cGAS-STING pathway in a functional human STING-dependent manner.
BNBC induced ISG54-driven luciferase expression in HepAD38/cGAS-STING/ISG54 cells, did not induce luciferase expression in HepAD38/cGAS-STINGΔC/ISG54Luc cells that express human STING with truncation of carboxyl-terminal domain (CTD).
BNBC also concentration-dependently induced ISG54 driven luciferase expression in HepG2/STING/ISG54 reporter cells lacking cGAS.
BNBC induced a proinflammatory cytokine response and establishment of antiviral state in human foreskin fibroblast cells (THF) in a STING-dependent manner.
Pretreatment of THF cells with BNBC inhibited the replication of Dengue, Yellow fever, and Zika viruses. induced inflammatory cytokine response in human PBMCs and promoted PBMC-derived dendritic cell maturation.
BNBC activated type I and III interferon dominated inflammatory cytokine response in PBMC-derived dendritic cells..
BNBC induced the expression of interferon and other proinflammatory cytokines in HepG2 cells expressing functional human, but not mouse STING.
| M.Wt | 370.202 | |
| Formula | C18H12BrNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang X, et al. ACS Infect Dis. 2019 May 14. doi: 10.1021/acsinfecdis.9b00010.
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