STING agonist C11 |CAS:875863-22-2 Probechem Biochemicals

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Chemical Structure : STING agonist C11

STING agonist C11

Catalog No.: PC-61228Not For Human Use, Lab Use Only.

STING agonist C11 is a novel cell-permeable STING agonist that activates IFN-dependent signaling processes and induces IFN secretion from human cells.

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Biological Activity

STING agonist C11 is a novel cell-permeable STING agonist that activates IFN-dependent signaling processes and induces IFN secretion from human cells.
STING agonist C11 induces transcription and translation of interferon-dependent antiviral genes, induces canonical IRF3 phosphorylation and ISG transcription in a manner that requires STING but not MAVS or TRIF.
STING agonist C11 potently blocks replication of multiple emerging Alphavirus types including Chikungunya, Ross River, Mayaro, and O'nyong'nyong viruses.

Physicochemical Properties

M.Wt	382.438
Formula	C19H18N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(Methylcarbamoyl)-2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-phenylacetamide

References

1. Gall B, et al. J Virol. 2017 Dec 20. pii: JVI.01913-17.

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