Chemical Structure : STING agonist C92
CAS No.:
2259308-68-2
STING agonist C92
Catalog No.: PC-27124Not For Human Use, Lab Use Only.
STING agonist C92 is a potent, allosteric hSTING agonist with EC50 of 36.2 nM for enhancement of the association of [3H]cGAMP (1 nM) to STING.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
STING agonist C92 is a potent, allosteric hSTING agonist with EC50 of 36.2 nM for enhancement of the association of [3H]cGAMP (1 nM) to STING.
C92 activates the cGAS/STING pathway in human primary cells.
C92 activates a strong IFN-I response through phosphorylation of STING and IRF3, induces STING protein oligomerization and phosphorylation of STING and IRF3.
C92 (1) does not induce autophagy, (2) does not require downstream trafficking of STING from the ER to Golgi for activation of IRF3, (3) does not reduce levels of STING and, (4) does not promote pyroptosis and hyperinflammation.
Systemic administration of C92 leads to activation of the STING pathway and TGR in vivo.
Physicochemical Properties
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M.Wt
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505.90
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Formula
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C25H20ClF4N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-1-(2-chloro-6-fluorobenzyl)-3,4-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
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References
1. Banerjee M, et al. J Immunother Cancer. 2026 Jun 23;14(6):e015242.
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