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Chemical Structure : STING agonist diABZI compound 3
CAS No.: 2138299-34-8
Catalog No.: PC-35785Not For Human Use, Lab Use Only.
STING agonist diABZI compound 3 (diABZI-3) is an amidobenzimidazole (ABZI)-based compound that functions as a potent, specific, non-nucleotide STING agonist, induces dose-dependent activation of STING and secretion of IFN-β with EC50 of 130 nM in human PBMCs.
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STING agonist diABZI compound 3 (diABZI-3) is an amidobenzimidazole (ABZI)-based compound that functions as a potent, specific, non-nucleotide STING agonist, induces dose-dependent activation of STING and secretion of IFN-β with EC50 of 130 nM in human PBMCs.
STING agonist diABZI compound 3 is more than 400-fold more potent than cGAMP, also demonstrates high selectivity against >350 kinases.
STING agonist diABZI compound 3 activates secretion of IFNβ, IL-6, TNF, and KC/GROα (also known as CXCL1) in wild-type but not Sting−/− mice, induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo via subcutaneous injection.
STING agonist diABZI compound 3 exhibits durable anti-tumour effect and causes complete tumour regression in syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.
| M.Wt | 959.328 | |
| Formula | C42H54Cl3N13O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1Hbenzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1Hbenzo[d]imidazole-5-carboxamide tris hydrochloride |
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1. Ramanjulu JM, et al. Nature. 2018 Nov 7. doi: 10.1038/s41586-018-0705-y.
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