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Chemical Structure : STING degrader AK59
Catalog No.: PC-22439Not For Human Use, Lab Use Only.
STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation.
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STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation.
AK59-51TB able to induce the degradation of STING-SAVI mutants, induces STING degradation in CD14+ human PBMCs.
AK59-mediated STING degradation acts through the UPS involving HERC4, UBA5, and UBA6 as regulatory factors.
AK59 degrades STING by inducing its interaction with the E3 ligase HERC4.
| M.Wt | 429.42 | |
| Formula | C21H14F3N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mutlu M, et al. Nat Commun. 2024 May 29;15(1):4584.
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