STING degrader AK59 | STING degrader | Probechem Biochemicals

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Chemical Structure : STING degrader AK59

STING degrader AK59 (AK59-51TB)

Catalog No.: PC-22439Not For Human Use, Lab Use Only.

STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation.
AK59-51TB able to induce the degradation of STING-SAVI mutants, induces STING degradation in CD14+ human PBMCs.
AK59-mediated STING degradation acts through the UPS involving HERC4, UBA5, and UBA6 as regulatory factors.
AK59 degrades STING by inducing its interaction with the E3 ligase HERC4.

Physicochemical Properties

M.Wt	429.42
Formula	C21H14F3N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(pyridin-3-yl)quinolin-8-yl)-4-(trifluoromethyl)benzenesulfonamide

References

1. Mutlu M, et al. Nat Commun. 2024 May 29;15(1):4584.

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STING degrader AK59 (AK59-51TB)

Biological Activity

Physicochemical Properties

References

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