STING inhibitor 18 | STING inhibitor | Probechem Biochemicals

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Chemical Structure : STING inhibitor 18

STING inhibitor 18 (STING ligand-1)

Catalog No.: PC-24981Not For Human Use, Lab Use Only.

STING inhibitor 18 is a potent, orthosteric STING inhibitor / antagonist with IC50 of 68 nM in HAQ STING cGAMP displacement assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

STING inhibitor 18 is a potent, orthosteric STING inhibitor / antagonist with IC50 of 68 nM in HAQ STING cGAMP displacement assay.
STING inhibitor 18 displace cGAMP and stabilize the “open” conformation of STING, a key assumption is that stabilizing the “open” conformation will prevent all STING signaling.
STING inhibitor 18 exhibits good oral exposure, slow binding kinetics, and functional inhibition of STING-mediated cytokine release.

Physicochemical Properties

M.Wt	523.99
Formula	C29H27ClFNO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3S,4S)-2-(4-(tert-butyl)-3-chlorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-7-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)acetic acid

References

1. Tony Siu, et al. ACS Med Chem Lett. 2018 Dec 6;10(1):92-97.

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STING inhibitor 18 (STING ligand-1)

Biological Activity

Physicochemical Properties

References

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