STING inhibitor 18 |CAS 2377104-08-8 Probechem Biochemicals

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Chemical Structure : STING inhibitor 18

STING inhibitor 18

Catalog No.: PC-36011Not For Human Use, Lab Use Only.

STING inhibitor 18 is a novel cGAMP competitive ligand (antagonist) of the inactive form of STING with IC50 of 68 nM in the HAQ STING cGAMP displacement assays.

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Biological Activity

STING inhibitor 18 is a novel cGAMP competitive ligand (antagonist) of the inactive form of STING with IC50 of 68 nM in the HAQ STING cGAMP displacement assays.
STING inhibitor 18 does not stimulate IFNβ production (EC50=>30000 nM), but modestly inhibits cGAMP-induced IFNβ production (EC50=1.1 uM).
STING inhibitor 18 demonstrates slow dissociation kinetics, good oral bioavailability, and ability to inhibit cGAMP dependent signaling in vitro.

Physicochemical Properties

M.Wt	509.958
Formula	C28H25ClFNO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4S)-2-(4-(tert-butyl)-3-chlorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-7-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid

References

1. Siu T, et al. ACS Med Chem Lett. 2018 Dec 6;10(1):92-97.

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