STING inhibitor 42

Chemical Structure : STING inhibitor 42

Catalog No.: PC-23966Not For Human Use, Lab Use Only.

STING inhibitor 42 is a potent, orally bioavailable STING inhibitor with IC50 of 34.2 nM and 7.1 nM for human and murine STING respectively.

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Biological Activity

STING inhibitor 42 is a potent, orally bioavailable STING inhibitor with IC50 of 34.2 nM and 7.1 nM for human and murine STING respectively.
STING inhibitor 42 dose-dependently suppressed the induction of STING downstream genes (e.g., IFNB, ISG15, CXCL10, and IL6) expression in THP1 and L929 cells activated by 2′,3′-cGAMP.
STING inhibitor 42 could block the STING palmitoylation induced by 2′,3′-cGAMP in THP1 cells.
STING inhibitor 42 (10 mg/kg, oral) significantly suppressed STING-related inflammatory response in the CMA-treated model and Trex1–/– mouse model.

Physicochemical Properties

M.Wt	403.86
Formula	C21H20ClF2N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-Chloro-1H-indol-3-yl)-3-(4-(4,4-difluorocyclohexyl)phenyl)urea

References

1. Han X, et al. J Med Chem. 2025 Jan 28. doi: 10.1021/acs.jmedchem.4c02200.