STING inhibitor C-176 |CAS:314054-00-7 Probechem Biochemicals

Chemical Structure : STING inhibitor C-176

CAS No.: 314054-00-7

STING inhibitor C-176 (STING inhibitor C176)

Catalog No.: PC-35311Not For Human Use, Lab Use Only.

STING inhibitor C-176 (C176) is a covalent, in vivo-active, small-molecule inhibitor of STING, attenuates STING-associated autoinflammatory disease in mice.

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Biological Activity

STING inhibitor C-176 (C176) is a covalent, in vivo-active, small-molecule inhibitor of STING, attenuates STING-associated autoinflammatory disease in mice.
C176 markedly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6 in vivo.
C176 directly targets mouse STING (mmSTING) but not human STING (hsSTING).

Physicochemical Properties

M.Wt	358.091
Formula	C11H7IN2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-iodophenyl)-5-nitrofuran-2-carboxamide

References

1. Haag SM, et al. Nature. 2018 Jul 4. doi: 10.1038/s41586-018-0287-8.

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STING inhibitor C-176 (STING inhibitor C176)

Biological Activity

Physicochemical Properties

References

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