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STING inhibitor C-178

Chemical Structure : STING inhibitor C-178

CAS No.: 329198-87-0

STING inhibitor C-178 (STING inhibitor C178)

Catalog No.: PC-35310Not For Human Use, Lab Use Only.

STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING.

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Biological Activity

STING inhibitor C-178 (C178) is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING.
C178 covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).

Physicochemical Properties

M.Wt 322.276
Formula C17H10N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide

References

1. Haag SM, et al. Nature. 2018 Jul 4. doi: 10.1038/s41586-018-0287-8.

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