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STING inhibitor THIQi

Chemical Structure : STING inhibitor THIQi

CAS No.: 2377105-91-2

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STING inhibitor THIQi

Catalog No.: PC-24980Not For Human Use, Lab Use Only.

STING inhibitor THIQi is a potent, orthosteric STING inhibitor with IC50 of 84 nM in HAQ STING cGAMP displacement assays, inhibits cGAMP-induced IFNβ in PBMCs with IC50 of 29 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

STING inhibitor THIQi is a potent, orthosteric STING inhibitor with IC50 of 84 nM in HAQ STING cGAMP displacement assays, inhibits cGAMP-induced IFNβ in PBMCs with IC50 of 29 nM.

Physicochemical Properties

M.Wt 491.97
Formula C28H26ClNO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,4S)-2-(4-(tert-butyl)-3-chlorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid

References

1. Tony Siu, et al. ACS Med Chem Lett. 2018 Dec 6;10(1):92-97.

2. Xie T, et al. Nat Commun. 2025 Jul 1;16(1):5695.

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