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STX213

Chemical Structure : STX213

CAS No.: 415974-72-0

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STX213 (STX-213)

Catalog No.: PC-61430Not For Human Use, Lab Use Only.

STX213 is an orally active, second-generation steroid sulfatase (STS) inhibitor with IC50 of 0.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    STX213 is an orally active, second-generation steroid sulfatase (STS) inhibitor with IC50 of 0.5 nM.
    STX213 completely inhibits liver and tumor STS activity, and fully inhibits growth of MCF-7STS tumors in vivo.

    Physicochemical Properties

    M.Wt 420.524
    Formula C21H28N2O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Sulfamic acid, (4aS,4bR,10bS,12aS)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydro-12a-methyl-1,3-dioxo-2-propylnaphth[2,1-f]isoquinolin-8-yl ester

    References

    1. Foster PA, et al. Clin Cancer Res. 2006 Sep 15;12(18):5543-9.

    2. Foster PA, et al. Breast Cancer Res Treat. 2008 Sep;111(1):129-38.

    3. Foster PA, et al. Endocrinology. 2008 Aug;149(8):4035-42.

    4. Foster PA, et al. Clin Cancer Res. 2008 Oct 15;14(20):6469-77.

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