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Chemical Structure : STX681
Catalog No.: PC-61432Not For Human Use, Lab Use Only.
STX681 is a potent, orally active, dual-acting aromatase and steroid sulfatase (STS) inhibitor with IC50 of 0.82 nM and 39 nM, respectively.
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STX681 is a potent, orally active, dual-acting aromatase and steroid sulfatase (STS) inhibitor with IC50 of 0.82 nM and 39 nM, respectively.
STX681 significantly reduces plasma E2 levels, completely inhibits the growth of both MCF-7(STS) tumor growth and MCF-7(AROM) tumor in a xenograft nude mouse model.
| M.Wt | 449.283 | |
| Formula | C16H13BrN6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Foster PA, et al. Clin Cancer Res. 2008 Oct 15;14(20):6469-77.
2. Woo LW, et al. J Med Chem. 2007 Jul 26;50(15):3540-60.
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