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STX681

Chemical Structure : STX681

CAS No.: 537674-89-8

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STX681 (STX-681)

Catalog No.: PC-61432Not For Human Use, Lab Use Only.

STX681 is a potent, orally active, dual-acting aromatase and steroid sulfatase (STS) inhibitor with IC50 of 0.82 nM and 39 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    STX681 is a potent, orally active, dual-acting aromatase and steroid sulfatase (STS) inhibitor with IC50 of 0.82 nM and 39 nM, respectively.
    STX681 significantly reduces plasma E2 levels, completely inhibits the growth of both MCF-7(STS) tumor growth and MCF-7(AROM) tumor in a xenograft nude mouse model.

    Physicochemical Properties

    M.Wt 449.283
    Formula C16H13BrN6O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Sulfamic acid, 2-bromo-4-[[(4-cyanophenyl)-4H-1,2,4-triazol-4-ylamino]methyl]phenyl ester

    References

    1. Foster PA, et al. Clin Cancer Res. 2008 Oct 15;14(20):6469-77.

    2. Woo LW, et al. J Med Chem. 2007 Jul 26;50(15):3540-60.

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