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SU0383

Chemical Structure : SU0383

CAS No.: 2598151-90-5

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SU0383 (SU 0383, SU-0383)

Catalog No.: PC-72025Not For Human Use, Lab Use Only.

SU0383 (SU 0383) is a potent, dual inhibitor of repair enzyme OGG1 and NUDT1 (MTH1) with IC50 of 34 nM and 490 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SU0383 (SU 0383) is a potent, dual inhibitor of repair enzyme OGG1 and NUDT1 (MTH1) with IC50 of 34 nM and 490 nM, respectively.
    SU0383 displayed low toxicity in two human cell lines at 10 uM, SU0383 increases sensitivity of tumor cells to oxidative stress.

    Physicochemical Properties

    M.Wt 626.732
    Formula C33H34N6O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO (6.3 mg/mL)
    Chemical Name/SMILES

    N-(2-((2-Amino-5-methylpyrimidin-4-yl)oxy)ethyl)-4'-(N-(1-(cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide

    References

    1. Tahara YK, et al. ACS Chem Biol. 2019 Dec 20;14(12):2606-2615.

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