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SU0448

Chemical Structure : SU0448

CAS No.: 2803422-60-6

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SU0448 (SU-0448)

Catalog No.: PC-49111Not For Human Use, Lab Use Only.

SU0448 is a specific, cell-permeable small molecule activator of the DNA repair enzyme Human MutT Homolog 1 (MTH1) with AC50 value of 5.5 uM, inhibits cell viability of HCC1806 cells with IC50 of 36.1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SU0448 is a specific, cell-permeable small molecule activator of the DNA repair enzyme Human MutT Homolog 1 (MTH1) with AC50 value of 5.5 uM, inhibits cell viability of HCC1806 cells with IC50 of 36.1 uM.
    SU0448 showed intracellular interaction with MTH1 and over 200% activation in HCC1806 cells at 20 uM, does not change MTH1 protein expression.
    SU0448 reduces genomic DNA damage both in cancerous and noncancerous cells regardless of endogenous MTH1 protein level.
    SU0448 has little residual off-target kinase activity, very low toxicity, and favorable permeability properties.
    SU0448 can lower levels of 8-oxo-dG in cellular DNA substantially.

    Physicochemical Properties

    M.Wt 516.524
    Formula C29H23F3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(isoquinolin-5-ylethynyl)-N-(4-(morpholinomethyl)-3-(trifluoromethyl)phenyl)picolinamide

    References

    1. Yujeong Lee, et al. ACS Chem Biol. 2022 Jul 13. doi: 10.1021/acschembio.2c00038.

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