SU0617 | SMUG1 inhibitor | Probechem Biochemicals

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Chemical Structure : SU0617

SU0617 (SU-0617)

Catalog No.: PC-27097Not For Human Use, Lab Use Only.

SU0617 is a specific small molecule inhibitor of DNA repair enzyme SMUG1 with IC50 of 1.5 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SU0617 is a specific small molecule inhibitor of DNA repair enzyme SMUG1 with IC50 of 1.5 uM.
SU0617 demonstrates limted cross-inhibition against bacterial UDG and human NTHL1.
SU0617 is effective against different SMUG1 substrates (dU, 5-FdU, 5-OHdU, or 5-hmdU).
SU0617 is a useful tool for the study of base excision repair mechanisms involving SMUG1.

Physicochemical Properties

M.Wt	406.89
Formula	C21H15ClN4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenyl)nicotinamide

References

1. Thacker PS, et al. ACS Med Chem Lett. 2026 May 19;17(6):1285-1293.

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SU0617 (SU-0617)

Biological Activity

Physicochemical Properties

References

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