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SU 16f

Chemical Structure : SU 16f

CAS No.: 251356-45-3

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SU 16f (SU16f)

Catalog No.: PC-62329Not For Human Use, Lab Use Only.

SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively; inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 =0.11 uM).

Physicochemical Properties

M.Wt 386.451
Formula C24H22N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

References

1. Cao N, et al. Science. 2016 Jun 3;352(6290):1216-20.

2. Andersen RK, et al. Stem Cell Res Ther. 2015 Oct 8;6:196.

3. Lee E, et al. Sci Rep. 2014 Jul 28;4:5853.

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