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SUVN-G3031 free base

Chemical Structure : SUVN-G3031 free base

CAS No.: 1394808-82-2

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SUVN-G3031 free base (Samelisant free base)

Catalog No.: PC-35982Not For Human Use, Lab Use Only.

SUVN-G3031 (Samelisant) free base is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SUVN-G3031 (Samelisant) free base is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).
    SUVN-G3031 exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes.
    SUVN-G3031 reverses (R)-α-methylhistamine induced dipsogenia in vivo.

    Physicochemical Properties

    M.Wt 373.497
    Formula C21H31N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[4-(l-Cyclobutylpiperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide

    References

    1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280.

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