Chemical Structure : SV119
CAS No.:
1590379-84-2
SV119
(SV-119)
Catalog No.: PC-28286Not For Human Use, Lab Use Only.
SV119 is a high-affinity, specific small molecule Sigma-2 receptor (σ2R, σ2 receptor) ligand with Ki of 5.19 nM, has 273-fold selectivity over σ1R.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SV119 is a high-affinity, specific small molecule Sigma-2 receptor (σ2R, σ2 receptor) ligand with Ki of 5.19 nM, has 273-fold selectivity over σ1R.
SV119 induces apoptosis in a dose-dependent fashion in pancreas cancer cells.
SV119 potentiates conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma.
SV119 can specifically bind to pancreatic cancer cells and induces target cell death in vitro and in vivo.
Physicochemical Properties
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M.Wt
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403.57
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Formula
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C23H37N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Carbamic acid, N-(2-methoxy-5-methylphenyl)-, 9-(10-aminodecyl)-9-azabicyclo[3.3.1]non-3-yl ester
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References
1. Hotchkiss RS, et al. Mol Cancer. 2007 Jul 15;6:48.
2. Kashiwagi H, et al. J Transl Med. 2009 Mar 26;7:24.
3. Vangveravong S, et al. Bioorg Med Chem. 2006 Oct 15;14(20):6988-97.
4. Spitzer D, et al. Cancer Res. 2012 Jan 1;72(1):201-9.
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