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SW-083688

Chemical Structure : SW-083688

CAS No.: 422281-45-6

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SW-083688 (SW083688)

Catalog No.: PC-62728Not For Human Use, Lab Use Only.

SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.
    SW-083688 increases the abundance of p62 and inhibits autophagy.
    TAOK2 is an activator of p38 MAP kinase cascade that is up-regulated in response to environmental stresses, and a potential cancer therapeutic target.

    Physicochemical Properties

    M.Wt 455.529
    Formula C23H25N3O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-(3-ethoxypropyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide

    References

    1. Piala AT, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7.

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