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Chemical Structure : SW-083688
Catalog No.: PC-62728Not For Human Use, Lab Use Only.
SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.
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SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.
SW-083688 increases the abundance of p62 and inhibits autophagy.
TAOK2 is an activator of p38 MAP kinase cascade that is up-regulated in response to environmental stresses, and a potential cancer therapeutic target.
| M.Wt | 455.529 | |
| Formula | C23H25N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Piala AT, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7.
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