Chemical Structure : SW016789
CAS No.:
292613-04-8
SW016789
(SW 016789)
Catalog No.: PC-23747Not For Human Use, Lab Use Only.
SW016789 is a small molecule that acutely and chronically alters beta cell secretory responses, targets and activates VDAC1 to enhance Ca2+ influx and insulin release.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SW016789 is a small molecule that acutely and chronically alters beta cell secretory responses, targets and activates VDAC1 to enhance Ca2+ influx and insulin release.
SW016789 also impaires glucose-stimulated insulin secretion (GSIS) in solated human islets, does not impact cell viability, cell death, or the live/dead cell ratio.
SW016789 treatment potentiated nutrient- but not KCl-stimulated Ca2+ influx.
SW016789 does not impact oxygen consumption rate or canonical glycolysis and tricarboxylic acid (TCA) cycle metabolites in MIN6 beta cells.
SW016789 acutely synergizes with activators of protein kinase C and voltage-dependent calcium channels (VDCCs) to induce secretion.
SW016789 reduced the abundance of ER-associated degradation (ERAD).
Physicochemical Properties
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M.Wt
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349.45
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Formula
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C20H19N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(3-benzyl-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethan-1-ol
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References
1. Rodrigues-Dos-Santos K, et al. Endocrinology. 2022 Jul 1;163(7):bqac081.
2. Roy G, et al. bioRxiv [Preprint]. 2024 Dec 26:2024.12.26.629558.
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