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Chemical Structure : SW033291
CAS No.: 459147-39-8
Catalog No.: PC-45107Not For Human Use, Lab Use Only.
SW033291 (SW-033291) is a potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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SW033291 (SW-033291) is a potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM.
SW033291 increases PGE2 levels by 3.5-fold at 500 nM, with EC50 of 75 nM.
SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues, accelerates hematopoietic recovery in mice receiving a bone marrow transplant.
SW033291 also promotes tissue regeneration in mouse models of colon and liver injury.
| M.Wt | 412.5913 | |
| Formula | C21H20N2OS3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Thieno[2,3-b]pyridin-3-amine, 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)- |
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1. Zhang Y, et al. Science. 2015 Jun 12;348(6240):aaa2340.
2. Antczak MI, et al. J Med Chem. 2017 May 11;60(9):3979-4001.
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