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SW083688

Chemical Structure : SW083688

CAS No.: 422281-45-6

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SW083688 (SW-083688)

Catalog No.: PC-62728Not For Human Use, Lab Use Only.

SW083688 (SW-083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SW083688 (SW-083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.
    SW083688 increases the abundance of p62 and inhibits autophagy.
    TAOK2 is an activator of p38 MAP kinase cascade that is up-regulated in response to environmental stresses, and a potential cancer therapeutic target.

    Physicochemical Properties

    M.Wt 455.529
    Formula C23H25N3O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-(3-ethoxypropyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide

    References

    1. Piala AT, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7.

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