SW106 | PPR antagonist | Probechem Biochemicals

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Chemical Structure : SW106

SW106 (SW-106)

Catalog No.: PC-70262Not For Human Use, Lab Use Only.

SW106 is a potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SW106 is a potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM.
SW106 displays higher affinity for the PPR relative to the other GPCRs.
SW106 specificly blocks PTH-initiated cAMP accumulation.

Physicochemical Properties

M.Wt	361.312
Formula	C17H16F5NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,5S)-5-((E)-2-cyclopropylvinyl)-3-ethyl-6,7-difluoro-5-(trifluoromethyl)-1,5-dihydrobenzo[e][1,4]oxazepin-2(3H)-one

References

1. Carter PH, et al. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6846-51.

2. Carter PH, et al. Mol Endocrinol. 2015 Feb;29(2):307-21.

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SW106 (SW-106)

Biological Activity

Physicochemical Properties

References

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