Chemical Structure : SW157765
Catalog No.: PC-49286Not For Human Use, Lab Use Only.
SW157765 (SW 157765) is a potent, specific inhibitor of glucose transporter GLUT8 (SLC2A8) with Kd of 200 nM, shows sensitivity to KRAS/KEAP1 double mutant NSCLC cells.
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SW157765 (SW 157765) is a potent, specific inhibitor of glucose transporter GLUT8 (SLC2A8) with Kd of 200 nM, shows sensitivity to KRAS/KEAP1 double mutant NSCLC cells.
SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner.
Copy number-driven amplification of PHGDH expression together with high expression of CYP4F11 significantly corresponded to SW157765 sensitivity.
M.Wt | 331.33 | |
Formula | C19H13N3O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Elizabeth A McMillan, et al. Cell. 2018 May 3;173(4):864-878.e29.
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