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SW157765

Chemical Structure : SW157765

CAS No.: 332063-87-3

SW157765

Catalog No.: PC-49286Not For Human Use, Lab Use Only.

SW157765 (SW 157765) is a potent, specific inhibitor of glucose transporter GLUT8 (SLC2A8) with Kd of 200 nM, shows sensitivity to KRAS/KEAP1 double mutant NSCLC cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SW157765 (SW 157765) is a potent, specific inhibitor of glucose transporter GLUT8 (SLC2A8) with Kd of 200 nM, shows sensitivity to KRAS/KEAP1 double mutant NSCLC cells.
SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner.
Copy number-driven amplification of PHGDH expression together with high expression of CYP4F11 significantly corresponded to SW157765 sensitivity.

Physicochemical Properties

M.Wt 331.33
Formula C19H13N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(2-Furanyl)-N-[2-(4-pyridinyl)-5-benzoxazolyl]-2-propenamide

References

1. Elizabeth A McMillan, et al. Cell. 2018 May 3;173(4):864-878.e29.

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