SW208108 (SW 208108) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=14 nM).
SW208108 cross-linked to proteins that migrated at both 37kDa (p37) and 30kDa (p30), reflective of covalent modification, p37 and p30 represent the two known isoforms of SCD.
SW208108 inhibited SCD only in the sensitive cell line, H2122, but not in the insensitive cell line, H1155.
Cytochrome P450 4F11 (CYP4F11) is responsible for oxalamide activation in sensitive cell lines and it is not expressed in insensitive cell lines.
SW208108 inhibited SCD activity in microsomes derived from liver but not from preputial glands.
