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SW222746

Chemical Structure : SW222746

CAS No.: 2241676-74-2

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SW222746 (SW 222746, 15-PGDH inhibitor 49)

Catalog No.: PC-49523Not For Human Use, Lab Use Only.

SW222746 (SW 222746) is a potent selective, orally active inhibitor of 15-Prostaglandin dehydrogenase (15-PGDH) with IC50 of 3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SW222746 (SW 222746) is a potent selective, orally active inhibitor of 15-Prostaglandin dehydrogenase (15-PGDH) with IC50 of 3 nM.
    15-PGDH inhibitor 49 shows potent inhibition of 15-PGDH, good oral bioavailability, and protective activity in mouse models of ulcerative colitis and recovery from bone marrow transplantation.

    Physicochemical Properties

    M.Wt 398.47
    Formula C24H22N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-methyl-6-(7-(piperidine-1-carbonyl)quinoxalin-2-yl)isoquinolin-1(2H)-one

    References

    1. Bin Hu, et al. J Med Chem. 2022 Nov 24;65(22):15327-15343.
    2. Wei Huang, et al. Nat Commun. 2023 Feb 11;14(1):784.

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