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SW222746

Chemical Structure : SW222746

CAS No.: 2241676-74-2

SW222746 (SW 222746, 15-PGDH inhibitor 49)

Catalog No.: PC-49523Not For Human Use, Lab Use Only.

SW222746 (SW 222746) is a potent selective, orally active inhibitor of 15-Prostaglandin dehydrogenase (15-PGDH) with IC50 of 3 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SW222746 (SW 222746) is a potent selective, orally active inhibitor of 15-Prostaglandin dehydrogenase (15-PGDH) with IC50 of 3 nM.
15-PGDH inhibitor 49 shows potent inhibition of 15-PGDH, good oral bioavailability, and protective activity in mouse models of ulcerative colitis and recovery from bone marrow transplantation.

Physicochemical Properties

M.Wt 398.47
Formula C24H22N4O2
CAS No. 2241676-74-2
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name

2-methyl-6-(7-(piperidine-1-carbonyl)quinoxalin-2-yl)isoquinolin-1(2H)-one

References

1. Bin Hu, et al. J Med Chem. 2022 Nov 24;65(22):15327-15343.
2. Wei Huang, et al. Nat Commun. 2023 Feb 11;14(1):784.

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