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Chemical Structure : SW222746
Catalog No.: PC-49523Not For Human Use, Lab Use Only.
SW222746 (SW 222746) is a potent selective, orally active inhibitor of 15-Prostaglandin dehydrogenase (15-PGDH) with IC50 of 3 nM.
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SW222746 (SW 222746) is a potent selective, orally active inhibitor of 15-Prostaglandin dehydrogenase (15-PGDH) with IC50 of 3 nM.
15-PGDH inhibitor 49 shows potent inhibition of 15-PGDH, good oral bioavailability, and protective activity in mouse models of ulcerative colitis and recovery from bone marrow transplantation.
| M.Wt | 398.47 | |
| Formula | C24H22N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bin Hu, et al. J Med Chem. 2022 Nov 24;65(22):15327-15343.
2. Wei Huang, et al. Nat Commun. 2023 Feb 11;14(1):784.
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