SW43 | Sigma-2 receptor ligand | Probechem Biochemicals

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Chemical Structure : SW43

SW43 (SW-43)

Catalog No.: PC-28287Not For Human Use, Lab Use Only.

SW43 is a high-affinity, specific small molecule Sigma-2 receptor (σ2R, σ2 receptor) ligand with binding IC50 of 18 nM for inhibiting [125I]-ISO-2 binding to σ2R.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SW43 is a high-affinity, specific small molecule Sigma-2 receptor (σ2R, σ2 receptor) ligand with binding IC50 of 18 nM for inhibiting [125I]-ISO-2 binding to σ2R.
SW43 shows high affinity for pancreas cancer and decrease viability of AsPC1, BxPC3, Cfpac, Panc1, and MiaPaCa-2 with IC50 of 21-56 uM.
SW43 induces caspase-3 activation in pancreas cancer, generates reactive oxygen species (ROS).
SW43 enhances standard chemotherapy induced cell death in pancreas cancer.
SW43 decreases Panc02 tumor burden in C57BL/6, with minimal toxicity in vivo.

Physicochemical Properties

M.Wt	459.67
Formula	C27H45N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, N-(2-methoxy-5-methylphenyl)-, 9-(10-aminodecyl)-9-azabicyclo[3.3.1]non-3-yl ester

References

1. Hornick JR, et al. Mol Cancer. 2010 Nov 22;9:298.

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SW43 (SW-43)

Biological Activity

Physicochemical Properties

References

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