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SYC-435

Chemical Structure : SYC-435

CAS No.: 50405-58-8

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SYC-435 (SYC435, TC-E 5008)

Catalog No.: PC-35207Not For Human Use, Lab Use Only.

SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SYC-435 (TC-E 5008) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.
    SYC-435 is cell active and capable of significantly reducing D-2-HG production in an HT1080 fibrosarcoma cell line expressing IDH1 R132C (IC50=2.4 uM).

    Physicochemical Properties

    M.Wt 215.252
    Formula C13H13NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one

    References

    1. Liu Z, et al. J Med Chem. 2014 Oct 23;57(20):8307-18.

    2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159.

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