SZM594 | RIPK1/3 inhibitor | Probechem Biochemicals

Chemical Structure : SZM594

SZM594 (SZM-594)

Catalog No.: PC-26713Not For Human Use, Lab Use Only.

SZM594 (SZM-594) is a highly potent, dual inhibitor of RIPK1 and RIPK3 (RIPK1/3) with IC50 of 97 nM and 77 nM respectively, inhibits TSZ‐induced necroptosis in HT‐29 cells with EC50 of 0.17 uM.

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Biological Activity

SZM594 (SZM-594) is a highly potent, dual inhibitor of RIPK1 and RIPK3 (RIPK1/3) with IC50 of 97 nM and 77 nM respectively, inhibits TSZ‐induced necroptosis in HT‐29 cells with EC50 of 0.17 uM.

Physicochemical Properties

M.Wt	529.51
Formula	C26H19F4N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

References

1. Chen X, et al. Br J Pharmacol. 2019 Jun;176(12):2095-2108.

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SZM594 (SZM-594)

Biological Activity

Physicochemical Properties

References

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