Chemical Structure : SZV-2649
CAS No.:
SZV-2649
(SZV2649)
Catalog No.: PC-23125Not For Human Use, Lab Use Only.
SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects.
SZV-2649 (10 µM) decreases the densities of IKr, and Ito outward and INaL and ICaL inward currents in canine ventricular myocytes.
SZV-2649 (2.5–10 µM) elicits Class IB type Vmax reducing and Class III type action potential duration prolonging effects in dog right ventricular muscle preparations.
SZV-2649 (2.5–10 µM) moderately prolongs action potential duration in canine atrial muscle.
SZV-2649 inhibits several types of outward potassium currents including hERG/IKr and acetylcholine-activated outward potassium currents, hERG current more potently than IKr.
Physicochemical Properties
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M.Wt
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464.47
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Formula
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C10H11ClI2N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(2-aminopropoxy)-3,5-diiodobenzonitrile hydrochloride
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References
1. Mohammed ASA, et al. Sci Rep. 2024 Oct 5;14(1):23188.
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