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Chemical Structure : SZV-2649
Catalog No.: PC-23125Not For Human Use, Lab Use Only.
SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects.
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SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects.
SZV-2649 (10 µM) decreases the densities of IKr, and Ito outward and INaL and ICaL inward currents in canine ventricular myocytes.
SZV-2649 (2.5–10 µM) elicits Class IB type Vmax reducing and Class III type action potential duration prolonging effects in dog right ventricular muscle preparations.
SZV-2649 (2.5–10 µM) moderately prolongs action potential duration in canine atrial muscle.
SZV-2649 inhibits several types of outward potassium currents including hERG/IKr and acetylcholine-activated outward potassium currents, hERG current more potently than IKr.
| M.Wt | 464.47 | |
| Formula | C10H11ClI2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mohammed ASA, et al. Sci Rep. 2024 Oct 5;14(1):23188.
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