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Chemical Structure : Sabutoclax
Catalog No.: PC-63211Not For Human Use, Lab Use Only.
Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor that inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31, 0.32, 0.20 and 0.62 uM.
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Sabutoclax (BI-97C1) is a potent, pan Bcl-2 family proteins inhibitor that inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31, 0.32, 0.20 and 0.62 uM.
Sabutoclax (BI-97C1) potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines withEC50 of 0.13, 0.56, and 0.049 uM, respectively.
Sabutoclax (BI-97C1) displays superior single-agent antitumor efficacy in prostate cancer mouse xenograft model.
| M.Wt | 700.788 | |
| Formula | C42H40N2O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wei J, et al. J Med Chem. 2010 May 27;53(10):4166-76.
2. Dash R, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8785-90.
3. Azab B, et al. J Cell Physiol. 2012 May;227(5):2145-53.
4. Goff DJ, et al. Cell Stem Cell. 2013 Mar 7;12(3):316-28.
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