Catalog No.: PC-73444Not For Human Use, Lab Use Only.
Safimaltib (JNJ-67856633) is a potent, selective, allosteric inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) protease activity.
Safimaltib (JNJ-67856633) is a potent, selective, allosteric inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) protease activity.
Safimaltib (JNJ-67856633) inhibits proliferation of activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) cell lines bearing CD79b or CARD11 mutations as well as models mimicking resistance to covalent BTK inhibitors.
JNJ-67856633 showed activity in organoid cultures derived from ABC-DLBCL patients.
JNJ-67856633 leads to potent in vivo pharmacodynamic shutdown in CD79b- as well as CARD11-mutant ABC-DLBCL models as measured by serum IL10 or uncleaved BCL10 levels in tumors.
JNJ-67856633 exhibits potent tumor growth inhibition in two human DLBCL xenograft models, OCI Ly3 and OCI Ly10.
