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Safinamide

Chemical Structure : Safinamide

CAS No.: 133865-89-1

Safinamide (EMD1195686, FCE 26743)

Catalog No.: PC-45946Not For Human Use, Lab Use Only.

Safinamide (EMD1195686, FCE 26743) is a potent and selective inhibitor of monoamine oxidase B (MAO-B) with IC50 of 98 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Safinamide (EMD1195686, FCE 26743) is a potent and selective inhibitor of monoamine oxidase B (MAO-B) with IC50 of 98 nM.
Safinamide displays >5,000-fold selectivity over MAO-A.
Safinamide also inhibits glutamate release and dopamine reuptake, inhibits voltage-dependent Na+ and Ca2+ channels.
Safinamide is used for treatment ofParkinson's disease.

Physicochemical Properties

M.Wt 302.3434
Formula C17H19FN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Propanamide, 2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)-

References

1. Leonetti F, et al. J Med Chem. 2007 Oct 4;50(20):4909-16.

2. Strolin Benedetti MS, et al. J Pharm Pharmacol. 1994 Oct;46(10):814-9.

3. Caccia C, et al. Neurology. 2006 Oct 10;67(7 Suppl 2):S18-23.

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