Safingol | SphK inhibitor, PKC inhibitor

Chemical Structure : Safingol

Safingol (L-threo-dihydrosphingosine)

Catalog No.: PC-23349Not For Human Use, Lab Use Only.

Safingol (L-threo-dihydrosphingosine) is a putative inhibitor of sphingosine kinase (SphK) and PKCalpha (PKCα), suppresses growth of human oral squamous cell carcinoma (SCC) cells, significantly inhibits PKC isoforms.

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Biological Activity

Physicochemical Properties

M.Wt	301.52
Formula	C18H39NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-2-aminooctadecane-1,3-diol

References

1. Tsukamoto S, et al. Mol Cancer Ther. 2015 Oct;14(10):2303-12.

2. Dickson MA, et al. Clin Cancer Res. 2011 Apr 15;17(8):2484-92.

3. Coward J, et al. Autophagy. 2009 Feb;5(2):184-93.

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Safingol (L-threo-dihydrosphingosine)

Biological Activity

Physicochemical Properties

References

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