Chemical Structure : Saquinavir mesylate
CAS No.:
149845-06-7
Saquinavir mesylate
(Ro 31-8959/003)
Catalog No. : PC-45129Not For Human Use, Lab Use Only.
Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4512901
Biological Activity
Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays; binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus; inhibits both HIV-1 and HIV-2 proteases; used to treat or prevent HIV/AIDS.
HIV Infection
Approved
Physicochemical Properties
M.Wt
766.9465
Formula
C39H54N6O8S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-, methanesulfonate (1:1)
References
1. Martin JA, et al. Biochem Biophys Res Commun. 1991 Apr 15;176(1):180-8.
2. Craig JC, et al. Antiviral Res. 1991 Dec;16(4):295-305.
3. Kräusslich HG. J Virol. 1992 Jan;66(1):567-72.
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