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Saquinavir mesylate

Chemical Structure : Saquinavir mesylate

CAS No.: 149845-06-7

Saquinavir mesylate (Ro 31-8959/003)

Catalog No.: PC-45129Not For Human Use, Lab Use Only.

Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays.

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Biological Activity

Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays; binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus; inhibits both HIV-1 and HIV-2 proteases; used to treat or prevent HIV/AIDS.

HIV Infection

Approved

Physicochemical Properties

M.Wt 766.9465
Formula C39H54N6O8S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-, methanesulfonate (1:1)

References

1. Martin JA, et al. Biochem Biophys Res Commun. 1991 Apr 15;176(1):180-8.

2. Craig JC, et al. Antiviral Res. 1991 Dec;16(4):295-305.

3. Kräusslich HG. J Virol. 1992 Jan;66(1):567-72.

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