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Saredutant

Chemical Structure : Saredutant

CAS No.: 142001-63-6

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Saredutant (SR-48968, SR48968)

Catalog No.: PC-70189Not For Human Use, Lab Use Only.

Saredutant (SR48968) is a potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Saredutant (SR48968) is a potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.
    Saredutant (SR48968) displays >1,000-fold selectivity over NK3 receptor, and does not affect the effects of bradykinin, angiotensin or bombesin.
    Saredutant (SR48968) inhibits the bronchoconstriction induced by neurokinin A in guinea pigs>
    Saredutant (SR48968) inhibits the cholinergic response of the isolated guinea-pig main bronchus to electrical field stimulation.

    Physicochemical Properties

    M.Wt 552.5345
    Formula C31H35Cl2N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[(2S)-4-[4-(Acetylamino)-4-phenyl-1-piperidinyl]-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide

    References

    1. Emonds-Alt X, et al. Life Sci. 1992;50(15):PL101-6.

    2. Martin CA, et al. Eur J Pharmacol. 1993 Oct 26;243(3):309-12.

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