Satraplatin |CAS:129580-63-8 Probechem Biochemicals

Chemical Structure : Satraplatin

CAS No.: 129580-63-8

Satraplatin (BMS182751, BMY-45594, JM-216)

Catalog No.: PC-45364Not For Human Use, Lab Use Only.

Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis.

Packing	Price	Stock
5 mg	$228	In stock
10 mg	$378	In stock
25 mg	$598	In stock
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Biological Activity

Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis.
Satraplatin shows similar cytotoxicity and pattern of cytotoxicity to cisplatin against human ovarian carcinoma cell lines (IC50=1.7 uM).
Satraplatin shows antitumor selectivity far superior to cisplatin, carboplatin, or tetraplatin in vivo; orally active.

Physicochemical Properties

M.Wt	500.2816
Formula	C10H22Cl2N2O4Pt+2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Platinum, bis(acetato-κO)amminedichloro(cyclohexanamine)-, (OC-6-43)- (9CI)

References

1. Kelland LR, et al. Cancer Res. 1993 Jun 1;53(11):2581-6.

2. Mellish KJ, et al. Br J Cancer. 1993 Aug;68(2):240-50.

3. Ricart AD, et al. Clin Cancer Res. 2009 Jun 1;15(11):3866-71.

Satraplatin (BMS182751, BMY-45594, JM-216)

Biological Activity

Physicochemical Properties

References

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