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Chemical Structure : SecinH3
CAS No.: 853625-60-2
Catalog No.: PC-61174Not For Human Use, Lab Use Only.
SecinH3 is a selective inhibitor of small GEFs of the cytohesin family, blocks human, mouse and Drosophila cytohesins with IC50 of 2.4 to 5.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 100 mg | Get quote |
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SecinH3 is a selective inhibitor of small GEFs of the cytohesin family, blocks human, mouse and Drosophila cytohesins with IC50 of 2.4 to 5.6 uM.
SecinH3 binds to the Sec7 domain of these small Arf-GEFs but does not bind Sec7 domains of larger Arf-GEFs.
small GEFs prevents cytohesin-dependent insulin signaling in HepG2 cells, produces hepatic insulin resistance in mice.
| M.Wt | 460.5 | |
| Formula | C24H20N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)-acetamide |
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1. Hafner M, et al. Nature. 2006 Dec 14;444(7121):941-4.
2. Bi X, et al. Angew Chem Int Ed Engl. 2008;47(49):9565-8.
3. Yamauchi J, et al. Exp Cell Res. 2009 Jul 15;315(12):2043-52.
4. El Azreq MA, et al. J Immunol. 2010 Jan 15;184(2):637-49.
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